KEGG   REACTION: R00425
Entry
R00425                      Reaction                               
Name
GTP 7,8-8,9-dihydrolase (diphosphate-forming)
Definition
GTP + 4 H2O <=> Formate + 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 Orthophosphate
Equation
C00044 + 4 C00001 <=> C00058 + C01304 + 2 C00009
Comment
multi-step reaction
Reaction class
RC00293  C00044_C01304
RC02504  C00044_C00058
Enzyme
3.5.4.25
Pathway
rn00740  Riboflavin metabolism
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00125  Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
M00911  Riboflavin biosynthesis, fungi, GTP => riboflavin/FMN/FAD
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.25
     R00425  GTP + 4 H2O <=> Formate + 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 Orthophosphate
Orthology
K01497  GTP cyclohydrolase II [EC:3.5.4.25]
K14652  3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
Other DBs
RHEA: 23707

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (11338)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (11336)   
All databases (11360)   

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